#Angus sinclair childhood pdf#

Detection of human herpesvirus-6 and Epstein-Barr virus genome in childhood Hodgkin's disease.

Trovato R, Di Lollo S, Calzolari A, Torelli G, Ceccherini-Nelli L.

Epstein-Barr virus (EBV) and Hodgkin's disease in children: incidence of EBV latent membrane protein in malignant cells.

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Demonstration of Epstein-Barr viral DNA in formalin-fixed, paraffin-embedded samples of Hodgkin's disease.

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Childhood Hodgkin's disease in the United States: an analysis of histologic subtypes and association with Epstein-Barr virus.

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Epstein-Barr virus (EBV) latent membrane protein (LMP) in tumor cells of Hodgkin's disease in pediatric patients.

Preciado MV, De Matteo E, Diez B, Grinstein S.

Epstein-Barr virus (EBV) and Hodgkin's disease in a multi-ethnic population in Malaysia. High prevalence of Epstein-Barr virus in the Reed-Sternberg cells of Hodgkin's disease occurring in Peru.

Chang KL, Albújar PF, Chen YY, Johnson RM, Weiss LM.

Prevalence of Epstein-Barr virus sequences and correlations with histologic subtype.

Zarate-Osorno A, Roman LN, Kingma DW, Meneses-Garcia A, Jaffe ES.

Association of Epstein-Barr virus with pediatric Hodgkin's disease.

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Epstein-Barr virus-associated Hodgkin's disease: epidemiologic characteristics in international data.

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Epstein-Barr virus and childhood Hodgkin's disease in Honduras and the United States.

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Expression of Epstein-Barr virus latent gene products in tumour cells of Hodgkin's disease.

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#Angus sinclair childhood pdf#

The Full Text of this article is available as a PDF (128K). Furthermore, our data suggest that there is an association between poor prognosis and the non-detection of EBV products in South African childhood Hodgkin's lymphoma. Full clinical data were available for 36 cases EBV positive patients presented with less aggressive symptoms at diagnosis and had a significantly longer median survival than EBV negative patients.Ĭonclusions-The distribution of EBV in South African childhood Hodgkin's lymphoma follows a pattern intermediate to that of industrialised and non-industrialised countries.

Results-The nodular sclerosing subtype predominated, comprising 89% of cases the remaining 11% were of the mixed cellularity subtype. The correlation between the presence of the virus and clinical outcome was assessed. Methods-Immunohistochemistry (IHC) and in situ hybridisation (ISH) to detect EBV were performed on 47 South African children with classical Hodgkin's lymphoma, ranging in age from 3 to 14 years and coming from different ethnic backgrounds. Aim-To study the distribution of Hodgkin's lymphoma in South African children and report the incidence of Epstein-Barr virus (EBV) as regards age, race, sex, and histological subtype to investigate whether EBV is relevant to survival.